|
|
|
|
 |
2009 |
ICAAC |
Effect
of Food, Age and Gender on NXL103 Pharmacokinetics (PK) |
|
2009 |
ICAAC |
Multiple-dose
Safety, Pharmacokinetics (PK) and Pharmacodynamics (PD) of NXL103 |
|
2009 |
ICAAC |
A
Phase II double-blind, double-dummy, multicenter study of two doses
of linopristin/flopristin (NXL103) vs. amoxicillin in the treatment
of mild to moderate community acquired pneumonia (CAP) in adults |
|
2009 |
ICCAC |
Combined
Population (Pop) Pharmacokinetic (PK) Analysis of 6 Phase I Studies
with NXL103 |
|
2009 |
ICAAC |
Optimization
of the Linopristin / Flopristin Dose Ratio in NXL103 |
|
2009 |
ECCMID |
Antibacterial
Activity of NXL103 (linopristin/flopristin), against Intracellular
Staphylococcus aureus and Efficacy Following per oral
Administration in Murine Models of Systemic Infection |
|
2009 |
ECCMID |
Antibacterial
Activity of NXL103 (linopristin/flopristin), in vitro Post-antibiotic
Effect, and Spontaneous Frequency of Resistance |
|
2009 |
ECCMID |
Activity
of linopristin-flopristin (NXL103) Against Streptococcus pneumoniae,
Haemophilus influenzae, and Staphylococcus aureus |
|
2008 |
ICAAC |
Antistaphylococcal
Activity of NXL 103 (linopristine-flopristine) Compared to Other Agents |
|
2007 |
ICAAC |
Efficacy
of Oral NXL103 against Haemophilus influenzae and Streptococcus
pneumoniae in Mouse Pneumonia Models |
|
2007 |
ECCMID |
Pharmacokinetic
/ pharmacodynamic modelling of the plasma bactericidal activity of
NXL103 against Streptococcus pneumoniae and Staphylococcus
aureus in phase I studies |
|
2006 |
ECCMID |
NXL103-
Oral Streptogramin: A Phase I, Double-blind, Single Escalating oral
dose Study to Evaluate Safety, Tolerability and Pharmacokinetics in
Healthy adult male volunteers |
|
2006 |
BIACORE MEETING |
Exploitation
of BIACORE S51 data for compound development from hit selection to
pre-clinical studies |
|
2006 |
AntimicAgChemother |
Effects
of Various Media on the Activity of NXL103 (Formerly XRP 2868), a
New Oral Streptogramin, against Haemophilus influenzae |
|
2006 |
AntimicAgChemother |
Activity
of a New Oral Streptogramin, XRP2868, against Gram-Positive Cocci
Harboring Various Mechanisms of Resistance to Streptogramins |
|
2006 |
AntimicAgChemother |
Pharmacodynamics
of a New Streptogramin, XRP 2868, in Murine Thigh and Lung Infection
Models |
|
2006 |
Biochem Pharmacol |
Natural
products — The future scaffolds for novel antibiotics? |
|
2005 |
ICAAC |
Plasma
Bactericidal Titres of NXL103, a Novel Oral Streptogramin, after Single
Dose Administration of 0.5g, 1g and 1.5g to Healthy Volunteers. |
|
2005 |
ICAAC |
Comparative
Prevalence in European Union - Evaluation of the in vitro Activity
of NXL103 (Formerly XRP2868) and Macrolides Against Common Respiratory
Pathogens. |
|
2005 |
ECCMID |
Comparative
in vitro activity of XRP 2868, a new, oral streptogramin |
|
2005 |
Current Microbiology |
A
Comparison of a New Oral Streptogramin XRP 2868 with Quinupristin-Dalfopristin
Against Antibiotic-Resistant Strains of Haemophilus influenzae,
Staphylococcus aureus, and Streptococcus prneumoniae |
|
2005 |
Current Medicinal Chemistry |
Recent
Progress in the Field of Antibacterial Pristinamycins |
|
2005 |
AntimicAgChemother |
Comparative
In Vitro Activities of XRP 2868, Pristinamycin, Quinupristin-Dalfopristin,
Vancomycin, Daptomycin, Linezolid, Clarithromycin, Telithromycin,
Clindamycin, and Ampicillin against Anaerobic Gram-Positive Species,
Actinomycetes, and Lactobacilli |
|
2005 |
AntimicAgChemother |
In
Vitro Activity of an Oral Streptogramin Antimicrobial, XRP2868,
against Gram-Positive Bacteria |
|
2005 |
Chemical Reviews |
Streptogramins,
Oxazolidinones, and Other Inhibitors of Bacterial Protein Synthesis |
|
2003 |
AntimicAgChemother |
Activities
of a New Oral Streptogramin, XRP 2868, Compared to Those of Other
Agents against Streptococcus pneumoniae and Haemophilus
Species |
|
2002 |
ECCMID |
Design,
synthesis and in vitro evaluation of XRP2868, a new oral streptogramin
(PS135) |
|
2002 |
ECCMID |
Ex
vivo evaluation of RPR202868/RPR132552 (XRP2868), a new oral streptogramin
(PS136) |
|
2002 |
ECCMID |
In
vivo evaluation of XRP2868 (RPR202868/RPR132552), a new oral streptogramin
(PS137) |
|
2002 |
ECCMID |
XRP2868
(RPR202868/RPR132552), a new oral streptogramin: bactericidal activity
and pharmacokinetics in a model of Streptococcus pneumoniae mouse
pneumonia (PS138) |
|
1997 |
JAntimiChemother |
Inhibition
of protein synthesis by streptogramins and related antibiotics |
|
1996 |
Drugs |
Mechanism
of action of streptogramins and macrolides |
