List of all publications on linopristin/flopristin (NXL103)

2009 ICAAC Effect of Food, Age and Gender on NXL103 Pharmacokinetics (PK)
2009 ICAAC Multiple-dose Safety, Pharmacokinetics (PK) and Pharmacodynamics (PD) of NXL103
2009 ICAAC A Phase II double-blind, double-dummy, multicenter study of two doses of linopristin/flopristin (NXL103) vs. amoxicillin in the treatment of mild to moderate community acquired pneumonia (CAP) in adults
2009 ICCAC Combined Population (Pop) Pharmacokinetic (PK) Analysis of 6 Phase I Studies with NXL103
2009 ICAAC Optimization of the Linopristin / Flopristin Dose Ratio in NXL103
2009 ECCMID Antibacterial Activity of NXL103 (linopristin/flopristin), against Intracellular Staphylococcus aureus and Efficacy Following per oral Administration in Murine Models of Systemic Infection
2009 ECCMID Antibacterial Activity of NXL103 (linopristin/flopristin), in vitro Post-antibiotic Effect, and Spontaneous Frequency of Resistance
2009 ECCMID Activity of linopristin-flopristin (NXL103) Against Streptococcus pneumoniae, Haemophilus influenzae, and Staphylococcus aureus
2008 ICAAC Antistaphylococcal Activity of NXL 103 (linopristine-flopristine) Compared to Other Agents
2007 ICAAC Efficacy of Oral NXL103 against Haemophilus influenzae and Streptococcus pneumoniae in Mouse Pneumonia Models
2007 ECCMID Pharmacokinetic / pharmacodynamic modelling of the plasma bactericidal activity of NXL103 against Streptococcus pneumoniae and Staphylococcus aureus in phase I studies
2006 ECCMID NXL103- Oral Streptogramin: A Phase I, Double-blind, Single Escalating oral dose Study to Evaluate Safety, Tolerability and Pharmacokinetics in Healthy adult male volunteers
2006 BIACORE MEETING Exploitation of BIACORE S51 data for compound development from hit selection to pre-clinical studies
2006 AntimicAgChemother Effects of Various Media on the Activity of NXL103 (Formerly XRP 2868), a New Oral Streptogramin, against Haemophilus influenzae
2006 AntimicAgChemother Activity of a New Oral Streptogramin, XRP2868, against Gram-Positive Cocci Harboring Various Mechanisms of Resistance to Streptogramins
2006 AntimicAgChemother Pharmacodynamics of a New Streptogramin, XRP 2868, in Murine Thigh and Lung Infection Models
2006 Biochem Pharmacol Natural products — The future scaffolds for novel antibiotics?
2005 ICAAC Plasma Bactericidal Titres of NXL103, a Novel Oral Streptogramin, after Single Dose Administration of 0.5g, 1g and 1.5g to Healthy Volunteers.
2005 ICAAC Comparative Prevalence in European Union - Evaluation of the in vitro Activity of NXL103 (Formerly XRP2868) and Macrolides Against Common Respiratory Pathogens.
2005 ECCMID Comparative in vitro activity of XRP 2868, a new, oral streptogramin
2005 Current Microbiology A Comparison of a New Oral Streptogramin XRP 2868 with Quinupristin-Dalfopristin Against Antibiotic-Resistant Strains of Haemophilus influenzae, Staphylococcus aureus, and Streptococcus prneumoniae
2005 Current Medicinal Chemistry Recent Progress in the Field of Antibacterial Pristinamycins
2005 AntimicAgChemother Comparative In Vitro Activities of XRP 2868, Pristinamycin, Quinupristin-Dalfopristin, Vancomycin, Daptomycin, Linezolid, Clarithromycin, Telithromycin, Clindamycin, and Ampicillin against Anaerobic Gram-Positive Species, Actinomycetes, and Lactobacilli
2005 AntimicAgChemother In Vitro Activity of an Oral Streptogramin Antimicrobial, XRP2868, against Gram-Positive Bacteria
2005 Chemical Reviews Streptogramins, Oxazolidinones, and Other Inhibitors of Bacterial Protein Synthesis
2003 AntimicAgChemother Activities of a New Oral Streptogramin, XRP 2868, Compared to Those of Other Agents against Streptococcus pneumoniae and Haemophilus Species
2002 ECCMID Design, synthesis and in vitro evaluation of XRP2868, a new oral streptogramin (PS135)
2002 ECCMID Ex vivo evaluation of RPR202868/RPR132552 (XRP2868), a new oral streptogramin (PS136)
2002 ECCMID In vivo evaluation of XRP2868 (RPR202868/RPR132552), a new oral streptogramin (PS137)
2002 ECCMID XRP2868 (RPR202868/RPR132552), a new oral streptogramin: bactericidal activity and pharmacokinetics in a model of Streptococcus pneumoniae mouse pneumonia (PS138)
1997 JAntimiChemother Inhibition of protein synthesis by streptogramins and related antibiotics
1996 Drugs Mechanism of action of streptogramins and macrolides
This compilation was produced by Novexel SA, Romainville, France.